Cyclohexylamine → HCID 66703602, compound

Participants

Reaction Steps

In methylene chloride, ethyl 2,6-difluoronicotinate and cyclohexanamine were stirred at 0° C. for 0.5 hour to obtain ethyl 2-(cyclohexylamino)-6-fluoronicotinate (ES: 267). This was stirred in ethanol by adding sodium hydroxide. By concentrating the reaction liquid under a reduced pressure and purifying the resulting residue by silica gel column chromatography, 2-(cyclohexylamino)-6-fluoronicotinic acid was obtained.

Provenance & Evidence