Hydrazine → HCID 57867983, compound

HRID 425987Notes

Reaction equation

HRID 425987 reaction equation
NN.[CH3:3][C:4]1([CH3:29])[C:12]2[C:7](=[CH:8][C:9]([N:17]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:10][C:11]=2[C:13]([F:16])([F:15])[F:14])[NH:6][C:5]1=[O:28]>CO.C(Cl)(Cl)Cl>[NH2:17][C:9]1[CH:8]=[C:7]2[C:12]([C:4]([CH3:29])([CH3:3])[C:5](=[O:28])[NH:6]2)=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:10]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 57867994HCID 57867994, compound

Product 1

HCID 57867983HCID 57867983, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

By adding a hydrazine aqueous solution to a methanol-chloroform solution of 2-[3,3-dimethyl-2-oxo-4-(trifluoromethyl)-2,3-dihydro-1H-indol-6-yl]-1H-isoindol-1,3-(2H)-dione and carrying out the reaction at room temperature for 10 hours, 6-amino-3,3-dimethyl-4-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one was obtained.

Workup

  1. customthe reaction at room temperature for 10 hours

Sources & evidence

ORD record
ord-67bbc76a3330492fb3af42d713dc2387
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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