Ammonium formate → HCID 57867990, compound

Participants

Reaction Steps

Palladium-carbon and ammonium formate were added to a methanol solution of 2-[(1-benzylpiperidin-4-yl)amino]-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide, followed by heating under reflux for 2 hours. After spontaneous cooling, Celite filtration was carried out and then the filtrate was concentrated under a reduced pressure. By purifying the residue by silica gel column chromatography, N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-4-ylamino)-4-(trifluoromethyl)benzamide was obtained.

Provenance & Evidence