HCID 57867977, compound → HCID 57867944, compound

HRID 425996Notes

Reaction equation

HRID 425996 reaction equation
[Si:1]([O:8][CH2:9][CH2:10][N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([N+:21]([O-])=O)[CH:19]=2)[CH2:14][CH2:13][C:12]1=[O:24])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>[C].[Pd].C(O)C>[NH2:21][C:18]1[CH:19]=[C:20]2[C:15]([CH2:14][CH2:13][C:12](=[O:24])[N:11]2[CH2:10][CH2:9][O:8][Si:1]([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:2])[CH3:3])=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 57867977HCID 57867977, compound

Product 1

HCID 57867944HCID 57867944, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An ethanol solution of 1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-7-nitro-3,4-dihydroquinoline-2(1H)-one and 10% palladium-carbon was stirred at room temperature for 3 hours under an atmosphere of hydrogen (1 atm), the reaction liquid was filtered, and then the filtrate was concentrated under a reduced pressure. By purifying the residue by silica gel column chromatography, 7-amino-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3,4-dihydroquinolin-2(1H)-one was obtained.

Workup

  1. customthe reaction liquid
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated under a reduced pressure
  4. customBy purifying the residue by silica gel column chromatography

Sources & evidence

ORD record
ord-5ce72e2f168c4188a2485235b0a6b95b
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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