HCID 66703660, compound → HCID 66703627, compound

HRID 426002Notes

Reaction equation

HRID 426002 reaction equation
[CH:1]1([NH:7][C:8]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[Ni]>[NH2:11][CH2:10][C:9]1[CH:12]=[CH:13][CH:14]=[C:15]([C:16]([F:17])([F:18])[F:19])[C:8]=1[NH:7][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 66703660HCID 66703660, compound

Product 1

HCID 66703627HCID 66703627, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Under an atmosphere of hydrogen and in ethanol, catalytic hydrogenation reaction of 2-(cyclohexylamino)-3-(trifluoromethyl)benzonitrile was carried out in the presence of Raney nickel to obtain 2-(aminomethyl)-N-cyclohexyl-6-(trifluoromethyl)aniline.

Sources & evidence

ORD record
ord-d5f89351b79445debd35503853db6b67
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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