Dimethyl malonate → Dimethyl (2-chloro-4,6-dinitrophenyl)malonate

Participants

Reaction Steps

Sodium hydride was added under ice-cooling to a DMF solution of malonic acid dimethyl ester, and then 1,2-dichloro-3,5-dinitrobenzene was added thereto and allowed to undergo the reaction at room temperature overnight. By post-treating the reaction liquid, dimethyl (2-chloro-4,6-dinitrophenyl)malonate (Dat, FN: 332) was obtained. This was dissolved in DMSO, lithium chloride and water were added, followed by stirring at 100° C. for 2 hours. By post-treating the reaction liquid, methyl (2-chloro-4,6-dinitrophenyl)acetate was obtained.

Provenance & Evidence