Hydrogen chloride-ethyl acetate → HCID 66703606, compound

Participants

Reaction Steps

4 M hydrogen chloride/ethyl acetate solution (5 mL) was added to an ethanol (5 mL) solution of tert-butyl 2-{[(5-chloro-2-{[(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)amino]carbonyl}phenyl)amino]methyl}piperidin-1-carboxylate (540 mg), followed by stirring at room temperature for 2 hours. By collecting the resulting precipitate by filtration, 4-chloro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-[(piperidin-2-ylmethyl)amino]benzamide hydrochloride (470 mg) was obtained as a solid.

Provenance & Evidence