HRID42601

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11325

1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

C10H8BrNO2

结构：c1ccc(-c2nc3[nH]ncc3c(-c3ccccc3)c2-c2ccncc2)cc1

HCID67014853

未命名化合物

PRODUCTS

生成物

结构：O=C1c2ccccc2C(=O)N1CCn1cc2c(-c3ccccc3)c(-c3ccncc3)c(-c3ccccc3)nc2n1

HCID67014083

未命名化合物

收率 31%

PROCEDURE

实验过程

Following a similar procedure to that described in examples 6 and 7, but using 4,6-diphenyl-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine (obtained in example 2) instead of 4,6-bis(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine and N-(2-bromoethyl)phthalimide instead of iodoethane, the title compound was obtained (yield: 31%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-04e337fc91c94a5184a2716db9c83c69
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08536194B2
来源说明: uspto-grants-2013_09

反应 SMILES

[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[C:11]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:10]=[C:9]3[NH:25][N:26]=[CH:27][C:8]=23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:29][CH2:30][N:31]1[C:35](=[O:36])[C:34]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:33]2[C:32]1=[O:41]>>[C:1]1([C:7]2[C:8]3[C:9](=[N:25][N:26]([CH2:29][CH2:30][N:31]4[C:35](=[O:36])[C:34]5=[CH:37][CH:38]=[CH:39][CH:40]=[C:33]5[C:32]4=[O:41])[CH:27]=3)[N:10]=[C:11]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1