Hydrochloric Acid → HCID 66703635, compound

Participants

Reaction Steps

1 M Hydrochloric acid (0.37 mL) was added to an ethanol solution (1.5 mL) of N-[1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl]-2-(cyclohexylamino)-4-(trifluoromethyl)benzamide (220 mg), followed by stirring at room temperature for 5 hours. The reaction liquid was concentrated under a reduced pressure, and a sodium bicarbonate aqueous solution was added to the residue, followed by extraction with ethyl acetate. After drying the organic layer with sodium sulfate, the solution was concentrated under a reduced pressure. By purifying the residue by silica gel column chromatography (hexane:ethyl acetate, 2:1 to 2:3), 2-(cyclohexylamino)-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl]-4-(trifluoromethyl)benzamide (148 mg) was obtained as a solid.

Provenance & Evidence