HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(3-chlorophenyl)-3-(3-methoxypropoxy)propyl(isopropyl)carbamate → 3-(3-chlorophenyl)-N-isopropyl-3-(3-methoxypropoxy)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(3-chlorophenyl)-3-(3-methoxypropoxy)propyl(isopropyl)carbamate | HCID 66704397 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | 3-(3-chlorophenyl)-N-isopropyl-3-(3-methoxypropoxy)propan-1-amine | HCID 59364361 | — |
Reaction Steps
tert-butyl 3-(3-chlorophenyl)-3-(3-methoxypropoxy)propyl(isopropyl)carbamate was dissolved in a solution of 20% (V/V) TFA/CH2Cl2 (10 mL) and allowed to stir for 1 hour. The solvent and reagent were evaporated before re-dissolving in CH2Cl2 and washing with NaHCO3 saturated solution. The crude 3-(3-chlorophenyl)-N-isopropyl-3-(3-methoxypropoxy)propan-1-amine was isolated (138 mg) and used as is. MS ESI+ve m/z 299 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106221B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-84ada35b1772428f9256acec7af45064 |
| Source note | uspto-grants-2012_01 |