Triethylamine → HCID 59686849, compound

Participants

Reaction Steps

To a stirred solution of 2-chloro-6-(p-methoxybenzylamino)-4-pyridinemethanol (278 mg, 1 mmol) in chloroform (10 ml) at 0° C. (ice bath), was added triethylamine (210 μl, 1.5 mmol) and methanesulfonyl chloride (90 μl, 1.2 mmol). After stirring for 1.5 hr., the mixture was diluted with dichloromethane, washed with aqueous saturated sodium bicarbonate solution, dried with anhydrous magnesium sulfate, filtered, and evaporated in vacuo. The residue was further dried in high vacuo and mixed with (12) (285 mg, 1 mmol), anhydrous powdered potassium carbonate (138 mg, 1 mmol), lithium iodide (134 mg, 1 mmol). Anhydrous DMF (5 ml) was then added into the mixture and stirred for overnight at room temperature. The mixture was evaporated in vacuo. The residue was dissolved in methanol-dichloromethane (1:9), filtered through celite pad, and the filtrate was evaporated in vacuo to give a pale yellow foam. The crude product was purified by silica gel column chromatography (eluent, EA:hexanes (1:2)) to afford 244 mg (45%) of a white solid; 1H NMR (200 MHz, CD3OD/CDCl3) δ 1.10 (6H, d, J=7.0 Hz), 2.32 (3H, s), 2.62 (1H, m), 3.81 (3H, s), 4.31 (2H, s), 4.71 (2H, s), 5.98 (1H, s), 6.24 (1H, s), 6.76 (1H, s), 6.87-6.91 (3H, m), 7.18-7.28 (3H, m).

Provenance & Evidence