HCID 59184658, compound → HCID 59686846, compound

Participants

Reaction Steps

The solution of (57) (1.1 g, 2.237 mmol) in ethanol (20 ml) was stirred in the presence of 10% palladium on carbon under an atmosphere of hydrogen. After 1.5 hr., the mixture was filtered through celite pad and the filtrate was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluent, methanol:chloroform (5:95)) to afford 786 mg (quantitative) of the title compound as a white solid. m.p. 270-271° C.; 1H NMR (200 MHz, CDCl3) δ 1.00 (9H, s), 2.47 (3H, s), 7.70 (1H, s), 7.86 (1H, s), 8.02 (1H, s), 10.74 (1H, s), 11.01 (1H, s); m/z (EI) 311 (M+).

Provenance & Evidence