HRID42616

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75646

Cyclopropanemethanamine

C4H9N

结构：CS(=O)(=O)c1nccc(-c2cc3c(NC(=O)OCc4ccccc4)n[nH]c3nc2-c2cccc(C(F)(F)F)c2)n1

HCID68446303

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1n[nH]c2nc(-c3cccc(C(F)(F)F)c3)c(-c3ccnc(NCC4CC4)n3)cc12)OCc1ccccc1

HCID68446016

未命名化合物

PROCEDURE

实验过程

Following a similar procedure to that described in example 208, but starting from N-benzyloxycarbonyl-[5-(2-methylsulfonylpyrimidin-4-yl)-6-(3-trifluoromethylphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]amine (obtained in section b) and (cyclopropylmethyl)amine, the desired compound was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-00ecfd3894214fb388d83be8eab70ec7
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08536194B2
来源说明: uspto-grants-2013_09

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:20]2[C:15](=[N:16][C:17]([C:31]3[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=3)=[C:18]([C:21]3[CH:26]=[CH:25][N:24]=[C:23](S(C)(=O)=O)[N:22]=3)[CH:19]=2)[NH:14][N:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:41]1([CH2:44][NH2:45])[CH2:43][CH2:42]1>>[CH:41]1([CH2:44][NH:45][C:23]2[N:22]=[C:21]([C:18]3[CH:19]=[C:20]4[C:12]([NH:11][C:9]([O:8][CH2:1][C:2]5[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=5)=[O:10])=[N:13][NH:14][C:15]4=[N:16][C:17]=3[C:31]3[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=3)[CH:26]=[CH:25][N:24]=2)[CH2:43][CH2:42]1