反应详情

To a solution of 4-(4-benzyloxyphenyl)-6-(4-fluorophenyl)-2-methyl-5-(4-pyridyl)pyrazolo[3,4-b]pyridine (112 mg, 0.2 mmol, obtained in example 252) in EtOH (13 mL), 10% Pd/C (20 mg) was added and it was hydrogenated under atmospheric pressure at room temperature for 2 days. It was filtered through celite, washed with EtOH and concentrated. The crude product obtained was purified by chromatography on silica gel using hexane-EtOAc-MeOH mixtures of increasing polarity as eluent, to afford 61 mg of the title compound (yield: 67%)

1. filtrationIt was filtered through celite
2. washwashed with EtOH
3. concentrationconcentrated
4. customThe crude product obtained
5. customwas purified by chromatography on silica gel
6. temperatureof increasing polarity as eluent