4-Methoxybenzylamine → [2,3-Difluoro-6-(4-methoxy-benzylamino)-pyridin-4-yl]-methanol

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Reaction Steps

To a 100 ml round bottomed flask, were placed (2,3,6-trifluoro-pyridin-4-yl)-methanol (515 mg, 3.15 mmol) and p-methoxybenzyl amine (1.0 ml, 7.57 mmol). Nitrogen balloon was attached to the flask and the mixture was stirred in an oil bath (117˜130° C.) for 2.5 hr. After cooling to room temperature, the mixture was purified by silica gel column chromatography (eluent, dichloromethane: methanol (95:5)) to afford 838 mg (94%) of [2,3-difluoro-6-(4-methoxy-benzylamino)-pyridin-4-yl]-methanol as a pale brown solid. 1H NMR (200 MHz, CDCl3) δ 2.04 (1H, br. s), 3.79 (3H, s), 4.52 (2H, d, J=5.6 Hz), 4.70 (2H, br. s), 4.84 (1H, br. s), 6.22 (1H, m), 6.83-6.90 (2H, m), 7.24-7.31 (2H, m).

Provenance & Evidence