Cyclopropanemethanamine → HCID 136367828, compound

HRID 42625Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:25]3[CH:30]=[CH:29][N:28]=[C:27](S(C)(=O)=O)[N:26]=3)=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=3)[C:11]3[C:12](=[N:14][N:15]([CH3:17])[CH:16]=3)[N:13]=2)=[CH:4][CH:3]=1.[CH:35]1([CH2:38][NH2:39])[CH2:37][CH2:36]1>>[CH:35]1([CH2:38][NH:39][C:27]2[N:26]=[C:25]([C:9]3[C:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)=[N:13][C:12]4=[N:14][N:15]([CH3:17])[CH:16]=[C:11]4[C:10]=3[C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=3)[CH:30]=[CH:29][N:28]=2)[CH2:37][CH2:36]1

Participants

Reactant 2

HCID 75646Cyclopropanemethanamine

HCID 136334165HCID 136334165, compound

Product 1

HCID 136367828HCID 136367828, compound

Procedure

Following a similar procedure to that described in example 128, but starting from 4-[6-(4-fluorophenyl)-5-(2-methylsulfonylpyrimidin-4-yl)-2-methylpyrazolo[3,4-b]pyridin-4-yl]phenol (obtained in section b) and (cyclopropylmethyl)amine, the title compound was obtained.

Sources & evidence

ORD record: ord-9fc4107aa50442d4b4e55d870de1a87a
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08536194B2

Reaction notes

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