反应详情

温度

60 °C

Acetyl bromide (1 mL, excess) was added to 3-(5-cyclopropyl-2,6-dimethoxy-pyrimidine-4-carbonyl)-5-methyl-benzonitrile (31 mg, 0.096 mmol). The reaction was heated to 60° C. for 1 hour. The reaction was concentrated down and purified (silica gel, 20-80% EtOAc/hexane) to give white solid (22 mg, 77%). LC-MS shows 294.0 (M−1). 1H NMR (300 MHz, CDCl3): δ 8.04 (s, 1H), 7.97 (s, 1H), 7.75 (s, 1H), 2.50 (s, 3H), 1.17 (m, 1H), 0.56 (m, 2H), 0.49 (m, 2H).

1. concentrationThe reaction was concentrated down
2. custompurified (silica gel, 20-80% EtOAc/hexane)