反应详情

To a solution of 3-(5-bromo-2,6-dimethoxy-pyrimidine-4-carbonyl)-5-methyl-benzonitrile (0.158 g, 0.436 mmol) in acetyl bromide (2.0 mL) was heated at 65° C. for 24 h. Reaction mixture was concentrated and flash column chromatography (silica gel, 0 to 80% ethyl acetate/hexane) to give a yellow film (0.0802 g, 55%). 1H NMR (300 MHz, CD3OD): δ 8.18 (s, 1H), 8.09 (s, 1H), 7.90 (s, 1H), 2.46 (s, 3H). Mass spectrum: 335.3 (M+H)+.

1. customReaction mixture
2. concentrationwas concentrated
3. customflash column chromatography (silica gel, 0 to 80% ethyl acetate/hexane) to give a yellow film (0.0802 g, 55%)