HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorophenylboronic acid → 2-(2,4-Difluoro-4''-trifluoromethyl-[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorophenylboronic acid | HCID 2734334 | — |
| Reactant | 4-Methyl-2-(5-trifluoromethanesulfonyloxy-4'-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester | HCID 57755055 | — |
| Product | 2-(2,4-Difluoro-4''-trifluoromethyl-[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid | HCID 59004764 | — |
Reaction Steps
The title compound was prepared from a Suzuki coupling of 4-Methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester (intermediate Example 1g) with 2,4-difluorophenylboronic acid under the conditions described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106236B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-e003516a996e436a928524d81c7e1015 |
| Source note | uspto-grants-2012_01 |