HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(trifluoromethoxy)benzeneboronic acid → 2-(3-Fluoro-4-trifluoromethoxy-3'',5''-bis-trifluoromethyl[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(trifluoromethoxy)benzeneboronic acid | HCID 2783193 | — |
| Reactant | 4-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester | HCID 57754914 | — |
| Product | 2-(3-Fluoro-4-trifluoromethoxy-3'',5''-bis-trifluoromethyl[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid methyl ester | HCID 59004826 | 73% |
Reaction Steps
The title compound was prepared in 73% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Intermediate A) and 3-fluoro-4-trifluoromethoxyphenylboronic acid under the conditions described in Example 26, step (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106236B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ce18155c36c248039b6f715396ec126c |
| Source note | uspto-grants-2012_01 |