HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-fluorophenylboronic Acid → 2-(3-Fluoro-4-chloro-3'',5''-bis-trifluoromethyl[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-fluorophenylboronic Acid | HCID 2778656 | — |
| Reactant | 4-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester | HCID 57754914 | — |
| Product | 2-(3-Fluoro-4-chloro-3'',5''-bis-trifluoromethyl[1,1';3',1'']terphenyl-5'-yl)-4-methyl-pentanoic acid methyl ester | HCID 59004801 | 65% |
Reaction Steps
The title compound was prepared in 65% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Intermediate A) and 3-fluoro-4-chlorophenylboronic acid under the conditions described in Example 26, step (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106236B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-5605a177a6724c71bb0ca4218e9d9b13 |
| Source note | uspto-grants-2012_01 |