3,5-Bis-trifluoromethylphenylboronic acid → HCID 86616207, compound

HRID 426352Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11](C2C=C(C(F)(F)F)C=C(C(F)(F)F)C=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:38][C:39]([F:54])([F:53])[C:40]1[CH:41]=[C:42](B(O)O)[CH:43]=[C:44]([C:46]([F:49])([F:48])[F:47])[CH:45]=1>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:14]=[C:13]([C:43]2[CH:42]=[CH:41][C:40]([C:39]([F:54])([F:53])[F:38])=[CH:45][CH:44]=2)[CH:12]=[C:11]([C:42]2[CH:41]=[C:40]([C:39]([F:54])([F:53])[F:38])[CH:45]=[C:44]([C:46]([F:49])([F:48])[F:47])[CH:43]=2)[CH:10]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

Reactant 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acid

HCID 577549144-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester2×

Product 1

HCID 86616207HCID 86616207, compoundYield 68%

Procedure

The title compound was prepared in 68% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Intermediate A) and 3,5-bis-trifluoromethylphenylboronic acid under the conditions described in Example 26, step (d).

Sources & evidence

ORD record: ord-4d9bb6d066b0424ea3396885547f36ee
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106236B2

Reaction notes

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