4-Cyanophenylboronic acid → HCID 59004804, compound

HRID 426354Notes

Reaction equation

HRID 426354 reaction equation
[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[C:38]([C:40]1[CH:45]=[CH:44][C:43](B(O)O)=[CH:42][CH:41]=1)#[N:39]>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:30])[F:31])[CH:26]=[C:25]([C:33]([F:35])([F:34])[F:36])[CH:24]=2)[CH:12]=[C:13]([C:43]2[CH:44]=[CH:45][C:40]([C:38]#[N:39])=[CH:41][CH:42]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 577549144-Methyl-2-(5-trifluoromethanesulfonyloxy-3',5'-bis-trifluoromethyl-bi phenyl-3-yl)-pentanoic acid methyl ester2×

Product 1

HCID 59004804HCID 59004804, compoundYield 57%

Procedure

The title compound was prepared in 57% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Intermediate A) and 4-cyanophenylboronic acid under the conditions described in Example 26, step (d).

Sources & evidence

ORD record
ord-e279f9b2c9714d61810335d6ed8f92be
Source dataset
uspto-grants-2012_01
Patent number
US08106236B2

Reaction notes

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