4-Chlorophenol → Methyl 2-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionate

참여 물질

반응 단계

5.7 gm (0.044 mol) of 4-chloro-phenol and 10 gm (0.044 mol) of methyl 2-(4-chloromethyl-phenoxy)-propionate were added to a solution of 1.01 gm of sodium in 80 ml of ethanol, and the resulting mixture was refluxed for 6 hours, while stirring. Thereafter, the solvent was removed in vacuo, the residue was admixed with water, and the aqueous mixture was extracted with ether. The ethereal extract solution was washed with 1 N potassium hydroxide and then with water, dried and evaporated, leaving 11 gm of an oily residue which was purified by passing it through a silicagel column with benzene as the flow agent. The initially oily product crystallized upon standing and then had a melting point of 76° C.; it was identified to be the compound of the formula ##STR18##

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