2-Amino-4,6-dimethyl pyrimidine → HCID 20390813, compound

HRID 426444Notes

Reaction equation

HRID 426444 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[Cl:10][C:11]1[S:12][C:13]([Cl:22])=[CH:14][C:15]=1[S:16]([N:19]=[C:20]=[O:21])(=[O:18])=[O:17]>C(Cl)Cl>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([NH:1][C:20]([NH:19][S:16]([C:15]2[CH:14]=[C:13]([Cl:22])[S:12][C:11]=2[Cl:10])(=[O:17])=[O:18])=[O:21])[N:3]=1

Participants

4

Reactant 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 20390822HCID 20390822, compound

Product 1

HCID 20390813HCID 20390813, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 12 g of 2-amino-4,6-dimethylpyrimidine in 300 ml of methylene chloride was added at ambient temperature 26 g of 2,5-dichloro-3-thiophenesulfonyl isocyanate. After stirring for 16 hours, the resulting solution was evaporated to dryness and the desired product, obtained as a solid residue, was triturated with ethyl ether and filtered. The solid product thus obtained melted at 192°-194° and showed infrared absorption peaks at 1550 cm-1, 1605 cm-1, and 1690 cm-1.

Workup

  1. customthe resulting solution was evaporated to dryness

Sources & evidence

ORD record
ord-adab30278c164a0a9ba82a0ea8bc9c4f
Source dataset
uspto-grants-1979_10
Patent number
US04169719

Reaction notes

Loading…