HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Phenyl 2-(4-methylphenyl)-1,3-benzoxazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(4-Methylphenyl)-1,3-benzoxazole-5-carbonyl chloride | HCID 20390927 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Phenyl 2-(4-methylphenyl)-1,3-benzoxazole-5-carboxylate | HCID 20390931 | — |
Reaction Steps
A solution containing 4.43 g. (0.016 mole) of 2-(4-methylphenyl)-5-benzoxazolecarbonyl chloride in 50 ml. of methylene chloride was added dropwise to a solution containing 1.88 g. (0.02 mole) of phenol and 0.80 g. (0.02 mole) of sodium hydroxide in 25 ml. of water. After stirring at 50° for 20 hours, the layers were separated and the organic layer was dried (MgSO4) and concentrated to give 2.9 g. (54%) of ld: UV (CH2Cl2) λmax 306 nm (18,200), ε325 =3500.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04169837 |
| Source dataset | uspto-grants-1979_10 |
| ORD ID | ord-142236d7dd164d289ccb7f65e6577e66 |
| Source note | uspto-grants-1979_10 |