Chloroform → HCID 53899050, compound

HRID 426454Notes

Reaction equation

HRID 426454 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([C:17](Cl)=[O:18])=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[OH:20][C:21]1[CH:34]=[C:33]([OH:35])[CH:32]=[CH:31][C:22]=1[C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:24].[OH-].[Na+].C(Cl)(Cl)Cl>O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([C:17]([O:35][C:33]4[CH:32]=[CH:31][C:22]([C:23](=[O:24])[C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)=[C:21]([OH:20])[CH:34]=4)=[O:18])=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 6212ChloroformHCID 85722,4-DihydroxybenzophenoneHCID 14798Sodium HydroxideHCID 203909272-(4-Methylphenyl)-1,3-benzoxazole-5-carbonyl chloride

Product 1

HCID 53899050HCID 53899050, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution containing 5.42 g. (0.02 mole) of 1c, 4.28 g. (0.02 mole) of 2,4-dihydroxybenzophenone, and 0.8 g. (0.02 mole) of sodium hydroxide in 50 ml. of chloroform and 15 ml. of water was refluxed for 3 hours. After cooling, the layers were separated and the organic layer was concentrated to given 5.27 g. (59%) of 1e as a white crystalline solid: UV (CH2Cl2) λmax 306 nm (31,000), ε325 =18,500.

Workup

  1. additionA solution containing 5.42 g
  2. temperatureAfter cooling
  3. customthe layers were separated
  4. concentrationthe organic layer was concentrated

Sources & evidence

ORD record
ord-49dfceb35f0b49dbb98e410c5ea00ad7
Source dataset
uspto-grants-1979_10
Patent number
US04169837

Reaction notes

Loading…