Acetic Anhydride → 1-[4-Phenyl-3-(4H-1,2,4-triazol-4-yl)-1H-pyrazol-1-yl]ethan-1-one

HRID 426456Notes

Reaction equation

HRID 426456 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][NH:10][C:11]=2[N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([N:9]1[CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:11]([N:12]2[CH:13]=[N:14][N:15]=[CH:16]2)=[N:10]1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 123305444-(4-Phenyl-1H-pyrazol-5-yl)-4H-1,2,4-triazole

Product 1

HCID 123305531-[4-Phenyl-3-(4H-1,2,4-triazol-4-yl)-1H-pyrazol-1-yl]ethan-1-one

Procedure

A suspension of 4-(4-phenyl-5-pyrazolyl)-4H-1,2,4-triazole (1.0 g) in acetic anhydride is refluxed until a clear solution is obtained. The solution is poured into ice water and stirred for 1/2 hour. The yellowish solid is collected and recrystallized from a mixture of chloroform/hexane, giving a white powder, m.p. 165° C. to 168° C. Similarly prepared is the propionyl derivative.

Workup

  1. temperatureis refluxed until a clear solution
  2. customis obtained
  3. customThe yellowish solid is collected
  4. customrecrystallized from a mixture of chloroform/hexane
  5. customgiving a white powder, m.p. 165° C. to 168° C
  6. customSimilarly prepared

Sources & evidence

ORD record
ord-1eb6a03bcb854bc98c57de06446305de
Source dataset
uspto-grants-1979_10
Patent number
US04169838

Reaction notes

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