Water → HCID 22808649, compound

Participants

Reaction Steps

Water (10 ml) is added to a solution of 30 g of 5-(p-chlorobenzamido)-3-(2-dimethylaminoethyl)-6,6-dimethyl-2-thioxo-tetrahydro-2H-1,3-thiazin-4-one in 600 ml of ethyl acetate. The resulting mixture is stirred at room temperature for 5 days. The precipitate is collected by filtration, and washed with ethyl acetate. Thus is obtained N-(p-chlorobenzoyl)-S-(2-dimethylaminoethylthiocarbamoyl)-penicillamine as white crystals, melting at 142°-143° C. with decomposition.

Provenance & Evidence