Acetic Acid → HCID 20391101, compound

Participants

Reaction Steps

A mixture of 10 g of N-(p-chlorobenzoyl)-S-(2-dimethylaminoethylthiocarbamoyl)-penicillamine, 2 g of glacial acetic acid and 100 ml of chloroform is stirred under reflux for 5 hours. The solvent is then removed under reduced pressure, and the crude product is recrystallized from a mixture of ethyl acetate and isopropyl ether to give 5-(p-chlorobenzamido)-3-(2-dimethylaminoethyl)-6,6-dimethyl-2-thioxo-tetrahydro-2H-1,3-thiazin-4-one as pale yellow crystals, melting at 152°-153° C.

Provenance & Evidence