Potassium Hydroxide → HCID 20390570, compound

HRID 426625Notes

Reaction equation

HRID 426625 reaction equation
C([O:4][CH2:5][CH:6]([N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)[CH2:7][O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1)(=O)C.[OH-].[K+]>CO.O>[N:19]1([CH:6]([CH2:7][O:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][CH:10]=2)[CH2:5][OH:4])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 53915022HCID 53915022, compound

Product 1

HCID 20390570HCID 20390570, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

A suspension of 2-piperidino-3-(1-naphthyloxy)-1-propanol acetate (6.4 g), 15% KOH in methanol (10 ml), methanol (10 ml) and water (20 ml) is heated at reflux for one hour. The reaction mixture is concentrated to dryness. The residue is taken up in diethyl ether. The ether extract is washed with water and concentrated to give the title compound as an oil, γmaxEtOH 319 nm (ε=1780), 350 nm (ε=3330), 288 nm (ε=6340), 230 nm (ε=30,600), 212 nm (ε=44,180).

Workup

  1. temperatureis heated
  2. temperatureat reflux for one hour
  3. concentrationThe reaction mixture is concentrated to dryness
  4. extractionThe ether extract
  5. washis washed with water
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-cb2fc0e3a545480ea22bfc3e8107c312
Source dataset
uspto-grants-1979_10
Patent number
US04170653

Reaction notes

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