Acetic Anhydride → HCID 13021429, compound

HRID 426639Notes

Reaction equation

HRID 426639 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[OH:11])[CH2:6][Cl:7])=[O:2].C([O:15][C:16](=[O:18])[CH3:17])(=O)C>>[C:1]([O:2][CH:1]([O:15][C:16](=[O:18])[CH3:17])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][C:10](=[O:11])[CH3:9])[CH2:6][Cl:7])(=[O:2])[CH3:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 3352915-(Chloromethyl)-2-hydroxybenzaldehyde

Product 1

HCID 13021429HCID 13021429, compoundYield 79%

Procedure

3-Formyl-4-hydroxy benzyl chloride (675 g., 3.96 moles) in 3.5 liters of acetic anhydride is refluxed for 24 hours. The reaction mixture is evaporated to dryness, triturated with a minimum amount of ether and filtered to yield 987 g (79%) of 3-(diacetoxymethyl)-4-acetoxybenzyl chloride, m.p. 93°-95°.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. customtriturated with a minimum amount of ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-b9482f6b82114341ac7def2467e790fa
Source dataset
uspto-grants-1979_10
Patent number
US04170654

Reaction notes

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