Hydrogen Peroxide → HCID 12694258, compound

Participants

Reaction Steps

A reaction mixture containing 52 g. of N-pyrrolidinylcarbonyl-2-methylthio-4,5-dimethoxyaniline 19.8 ml. of 31 percent aqueous hydrogen peroxide and 1 l. of glacial acetic acid was stirred for about 20 hours at ambient temperature. The reaction mixture was then concentrated under reduced pressure to a residual wax. The residue was dissolved in 1 l. of methylene chloride and the methylene chloride layer washed twice with water and then dried. Removal of the methylene chloride in vacuo yielded a residue comprising N-pyrrolidinylcarbonyl-2-methylsulfinyl-4,5-dimethoxyaniline which, after recrystallization from a benzene-hexane solvent mixture, yielded material melting at 124°-7° C. (80 percent yield).

Provenance & Evidence