Hydrogen Peroxide → HCID 20389820, compound

Participants

Reaction Steps

The resulting product, N-[2-methylthio-4,5-dimethoxyphenyl]-N',N'-diethylurea was oxidized with hydrogen peroxide to yield N-[2-methylsulfinyl-4,5-dimethoxyphenyl]-N',N'-diethylurea. Reaction of this compound with O-mesitylenesulfonylhydroxylamine yielded S-methyl-S-[2-diethylaminocarbonylamino-4,5-dimethoxyphenyl]sulfoximine. Heating the sulfoximine yielded 6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine-3(4H)-one-1-oxide melting at 333°-335° C. Total yield was 59 percent based on 2-methylthiol-4,5-dimethoxyaniline.

Provenance & Evidence