HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20389781, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 6-(Chloromethyl)-5,8-difluoro-2,3-dihydro-1,4-benzodioxin | HCID 20389767 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 20389781 | HCID 20389781 | — |
Reaction Steps
6-Chloromethyl-5,8-difluoro-1,4-benzodioxane (36.9 g, 0.183 mole) is dissolved in 500 ml of dimethylsulfoxide and 11.2 g (0.23 mole) of sodium cyanide added. This is stirred at 25° for 1 hour, and then poured into cold water. Extraction with ether, washing the extract with water, drying and concentration gives 6-cyanomethyl-5,8-difluoro-1,4-benzodioxane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04171359 |
| Source dataset | uspto-grants-1979_10 |
| ORD ID | ord-61c323a3f3914934ae25c97d1b65ac06 |
| Source note | uspto-grants-1979_10 |