反应详情

A mixture of 15 g of (3aRS,4SR,9aSR)-3a,4,9,9a-tetrahydro-4-phenyl-benz[f]isoindoline, 5.9 g of acrylic acid methyl ester and 1 cc of a 40% solution of benzyl trimethyl ammonium hydroxide in methanol is stirred at 50° for 4 hours and is then concentrated by evaporation. The evaporation residue is reduced to a slime with silica gel in benzene/ethyl acetate (9:1) and filtration is effected. Upon concentrating the filtrate by evaporation, the title compound, having a M.P. of 75°-76° (after crystallization from ether/petroleum ether), is obtained.

1. concentrationis then concentrated by evaporation
2. filtrationThe evaporation residue is reduced to a slime with silica gel in benzene/ethyl acetate (9:1) and filtration
3. concentrationUpon concentrating the filtrate
4. customby evaporation
5. customa M.P. of 75°-76° (after crystallization from ether/petroleum ether)
6. customis obtained