Formaldehyde → HCID 70608718, compound

Participants

Reaction Steps

A mixture of 1.5 g of (3aRS,4SR,9aSR)-6-chloro-4-(p-chlorophenyl)-3a,4,9,9a-tetrahydro-benz[f]isoindoline, 10 cc of 100% formic acid and 10 cc of a 40% aqueous formaldehyde solution is heated to the boil at reflux for 2 hours in an atmosphere of nitrogen. The mixture is concentrated by evaporation, the residue is taken up in water, the solution is made alkaline with concentrated caustic soda solution and is extracted with methylene chloride. Ether is added to the dried extracts until they are turbid, filtration through Hyflo and concentration by evaporation are effected, whereby the title compound is obtained as residue. M.P. 133°-135° (after crystallization from ether).

Provenance & Evidence