Sodium Hydroxide → HCID 70608306, compound

Participants

Reaction Steps

190 cc of 57% hydriodic acid are added dropwise to a suspension of 30 g of (9aRS)-2-benzyl-6-chloro-9,9a-dihydro-4-phenyl-benz[f]isoindoline and 46.8 g of red phosphorus in 400 cc of glacial acetic acid, the mixture is subsequently heated to 110° for 5 1/2 hours, is then poured on ice and made alkaline with caustic soda solution. After extraction with ethyl acetate, the organic phase is filtered through Celite, the filtrate is dried and concentrated by evaporation, whereby the title compound, having a M.P. of 115-117° (after crystallization from pentane), is obtained.

Provenance & Evidence