Sodium Hydroxide → HCID 70608931, compound

Participants

Reaction Steps

1 g of lithium aluminium hydride is added portionwise to a warm solution of 8.6 g of (3aRS,4SR,9aSR)-3a,4,9,9a-tetrahydro-4-phenyl-benz[f]-isoindoline-2-cyclopropylcarboxylic acid amide in 100 cc of tetrahydrofuran. The mixture is stirred at room temperature for 1 hour, is then decomposed with a 2 N caustic soda solution and filtered. The concentrated filtrate is reduced to a paste with silica gel in benzene/ethyl acetate (1:1), filtration and concentration by evaporation are effected, whereby the title compound, having a M.P. of 65-68° (after crystallization from pentane), is obtained.

Provenance & Evidence