化工社化工社 化学情報印刷レポート · 研究参考用
Toluene → 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid | HCID 2394006 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride | HCID 12047330 | — |
反応手順
A reaction vessel is charged with toluene, a catalytic amount of DMF (1-5% by weight of the amount of thionyl chloride employed) and 1 equivalent of 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid. While stirring, 1 to 4 equivalents of thionyl chloride are slowly added at 70 to 90° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536206B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-f4207449dcb14651907909ca79b85e5a |
| 出典メモ | uspto-grants-2013_09 |