1,3,6-Trimethyl-2,4(1H,3H)-pyrimidinedione → 5-Methylisocytosine

HRID 426824Notes

Reaction equation

HRID 426824 reaction equation
C[N:2]1C(C)=CC(=O)N(C)C1=O.C[N:13]1[CH:20]=[C:19]([CH3:21])[C:17](=[O:18])[N:16](C)[C:14]1=O.CN1C=C(CC2C=CC=CC=2)C(=O)N(C)C1=O>>[CH3:21][C:19]1[C:17](=[O:18])[NH:16][C:14]([NH2:2])=[N:13][CH:20]=1

Participants

4

Reactant 3

HCID 260751,3,6-Trimethyl-2,4(1H,3H)-pyrimidinedioneHCID 78112N,N-DimethylthymineHCID 3098301,3-Dimethyl-5-benzyluracil

Product 1

HCID 852215-Methylisocytosine

Procedure

In accordance with the above procedure, but where in place of 1,3,6-trimethyluracil there is employed 1,3,5-trimethyluracil or 1,3-dimethyl-5-benzyluracil, there is obtained the corresponding 5-methylisocytosine or 5-benzylisocytosine.

Sources & evidence

ORD record
ord-b15f898271254f1498159e92d9e8ef6b
Source dataset
uspto-grants-1979_10
Patent number
US04171429

Reaction notes

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