HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 3-Chlorobenzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 2-Amino-5-chlorobenzoic acid | HCID 12476 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chlorobenzoic Acid | HCID 447 | 89% |
Reaction Steps
172 parts of 5-chloroanthranilic acid are introduced into 550 parts of 45 percent strength by weight sulfuric acid and 600 parts of isopropanol. A solution of 100 parts of sodium nitrite in 140 parts of water is run in at 80° C. over 6 hours; nitrogen is evolved. The mixture is cooled, 1,500 parts of water are added and the product is filtered off. 140 parts (89% of theory) of 3-chlorobenzoic acid of melting point 151°-153° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04172098 |
| Source dataset | uspto-grants-1979_10 |
| ORD ID | ord-2e39d1deaec94a0cba9b4863c0cd3dcd |
| Source note | uspto-grants-1979_10 |