Ethylene Glycol → (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

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Reaction Steps

20 ml of ethane-1,2-diol are added dropwise at 50° C. to 11 g of residue and at the same time the 2-ethyl-1,3,2-dioxaborolane formed is distilled off in vacuo (10 Torr). The excess ethane-1,2-diol is removed in vacuo (10-3Torr, bath 80° C.). Approximately 40 ml of hexane are added to the highly viscous residue, the mixture is stirred for about 30 minutes and the white glucose is filtered off. 5 g (72%) of pure D-glucose are obtained after drying, mp. 146° C.

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