Ammonia → HCID 70547366, compound

HRID 426987Notes

Reaction equation

HRID 426987 reaction equation
[O:1]=[C:2]1[CH:7]=[C:6]([CH3:8])O[CH:4]=[C:3]1[O:9][CH2:10][C:11]([O:13]CC)=[O:12].[NH3:16]>>[OH2:1].[OH2:1].[O:1]=[C:2]1[CH:7]=[C:6]([CH3:8])[NH:16][CH:4]=[C:3]1[O:9][CH2:10][C:11]([OH:13])=[O:12]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20544441HCID 20544441, compound

Product 1

HCID 70547366HCID 70547366, compound

Conditions

Temperature
120 °C

Procedure

A mixture of ethyl 2-(4-oxo-6-methyl-4H-pyran-3-yloxy)acetate (6.36 g) and conc. ammonia (30 ml) was heated at 120° C. for 10 hours. The reaction mixture was concentrated, and water (50 ml) was added to the residue. The resultant aqueous mixture was adjusted to pH 2 to 3 with 10% hydrochloric acid. The resulting precipitates were collected by filtration and washed with wate to give crystals (4.5 g) of 2-(4-oxo-6-methyl-1,4-dihydropyridin-3-yloxy)acetic acid dihydrate, mp 235° to 236° C. (dec.).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionwater (50 ml) was added to the residue
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed with wate

Sources & evidence

ORD record
ord-a8e3f3ceaf8c4cb8a2c48713d768a6fc
Source dataset
uspto-grants-1979_10
Patent number
US04172198

Reaction notes

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