9-(2-Cyclohexenyl)-2-ethoxy-9H-adenine → HCID 12777844, compound

HRID 427012Notes

Reaction equation

HRID 427012 reaction equation
C1(N2C=NC3C2=NC(OCC)=NC=3N)CCCC=C1.[CH:20]1([N:26]2[CH:34]=[N:33][C:32]3[C:27]2=[N:28][C:29]([O:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])=[N:30][C:31]=3[NH2:35])[CH2:25][CH2:24][CH2:23][CH:22]=[CH:21]1>>[CH2:37]([O:36][C:29]1[N:28]=[C:27]2[C:32]([N:33]=[CH:34][N:26]2[CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)=[C:31]([NH2:35])[N:30]=1)[CH2:38][CH2:39][CH2:40][CH3:41]

Participants

3

Reactant 2

HCID 127778299-(2-Cyclohexenyl)-2-ethoxy-9H-adenineHCID 12777834HCID 12777834, compound

Product 1

HCID 12777844HCID 12777844, compoundYield 90%

Procedure

The procedure of Example 8 was repeated except that the 9-(2-cyclohexenyl)-2-ethoxy-9H-adenine used therein was replaced by an equivalent weight of 9-(2-cyclohexenyl)-2-n-pentyloxy-9H-adenine. There was produced the title product in 90% yield; m.p. 64°-68° C. IR(neat): 3500, 3320, 1635, 1590, 1460, 1395, 1340, 1325, 1265 cm-1. UV: λmaxEtOH 253 nm(ε 10900), 269 nm(ε 16800). NMR(CDCl3): 1.50(19H, m), 4.20(1H, m), 4.26(2H, t, J=6.5 Hz), 6.25(2H, s), 7.56(1H, s).

Sources & evidence

ORD record
ord-a26d817cb5e24ee2a1784d708af8bd0e
Source dataset
uspto-grants-1979_10
Patent number
US04172829

Reaction notes

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