9-(2-Cyclohexenyl)-2-ethoxy-9H-adenine → HCID 12777842, compound

HRID 427014Notes

Reaction equation

HRID 427014 reaction equation
C1(N2C=NC3C2=NC(OCC)=NC=3N)CCCC=C1.[CH:20]1([N:26]2[CH:34]=[N:33][C:32]3[C:27]2=[N:28][C:29]([O:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[N:30][C:31]=3[NH2:35])[CH2:25][CH2:24][CH2:23][CH:22]=[CH:21]1>>[CH2:37]([O:36][C:29]1[N:28]=[C:27]2[C:32]([N:33]=[CH:34][N:26]2[CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)=[C:31]([NH2:35])[N:30]=1)[CH:38]([CH3:40])[CH3:39]

Participants

3

Reactant 2

HCID 127778299-(2-Cyclohexenyl)-2-ethoxy-9H-adenineHCID 12777832HCID 12777832, compound

Product 1

HCID 12777842HCID 12777842, compoundYield 60%

Procedure

The procedure of Example 8 was repeated except that the 9-(2-cyclohexenyl)-2-ethoxy-9H-adenine used therein was replaced by an equivalent weight of 9-(2-cyclohexenyl)-2-isobutoxy-9H-adenine. There was produced the title product in 60% yield; m.p. 123°-134° C. IR(neat): 3320, 3160, 2940, 1635, 1590, 1395, 1375 cm-1. UV: λmaxEtOH 253 nm(ε 7000), 269 nm(ε 11000). NMR(CDCl3): 1.05(6H, d, J=6.5 Hz), 1.90(11H, m), 4.05(2H, d, J=6.5 Hz), 4.24(1H, m), 6.14(2H, s), 7.55(1H, s).

Sources & evidence

ORD record
ord-f91ecfe05b2141a7a5b6b1a6c4f0d9a5
Source dataset
uspto-grants-1979_10
Patent number
US04172829

Reaction notes

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