Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427022Generated: October 31, 2026

1-Fluoro-2-nitrobenzene → Methyl 3-(2-nitroanilino)thiophene-2-carboxylate

https://huagongshe.com/reaction/427022

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Fluoro-2-nitrobenzeneHCID 73895—
ReactantMethyl 3-amino-2-thiophenecarboxylateHCID 89652—
SolventToluene methanolHCID 21867641—
ProductMethyl 3-(2-nitroanilino)thiophene-2-carboxylateHCID 20387689—

Reaction Steps

The title compound was prepared using the process of Example 1(a) but with 2-fluoro-nitrobenzene and methyl 3-aminothiophene-2-carboxylate (U.K. Pat. No. 837,086) as starting materials, m.p. 184° C., (toluene/MeOH, 2:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04172831
Source datasetuspto-grants-1979_10
ORD IDord-e9ebbf5b277b408caa379353b5d66bf7
Source noteuspto-grants-1979_10