2,5-Difluoronitrobenzene → Ethyl 2-(4-fluoro-2-nitroanilino)-thiophene-3-carboxylate

HRID 427026Notes

Reaction equation

HRID 427026 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH2:12][C:13]1[S:14][CH:15]=[CH:16][C:17]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]>CCO>[F:8][C:5]1[CH:6]=[CH:7][C:2]([NH:12][C:13]2[S:14][CH:15]=[CH:16][C:17]=2[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Participants

4

Reactant 2

HCID 677672,5-DifluoronitrobenzeneHCID 1988156Ethyl 2-aminothiophene-3-carboxylate

Product 1

HCID 20387707Ethyl 2-(4-fluoro-2-nitroanilino)-thiophene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,5-Difluoro-nitrobenzene and ethyl 2-amino-thiophene-3-carboxylate, m.p. 125° C. (EtOH).

Sources & evidence

ORD record
ord-476f804a5d4e473e8897d7392181c933
Source dataset
uspto-grants-1979_10
Patent number
US04172831

Reaction notes

Loading…