2,5-Difluoronitrobenzene → Methyl 5-methyl-2-(2-nitro-4-fluoroanilino)-thiophene-3-carboxylate

HRID 427031Notes

Reaction equation

HRID 427031 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:11])=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].F[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[N+:20]([O-:22])=[O:21]>CCO>[CH3:11][C:4]1[S:3][C:2]([NH:1][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[N+:20]([O-:22])=[O:21])=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=1

Participants

4

Reactant 2

HCID 677672,5-DifluoronitrobenzeneHCID 675878Methyl-2-amino-5-methyl-3-thiophenecarboxylate

Product 1

HCID 20387797Methyl 5-methyl-2-(2-nitro-4-fluoroanilino)-thiophene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 2-amino-5-methyl-thiophene-3-carboxylate and 2,5-difluoronitrobenzene, m.p. 149°-151° C. (EtOH).

Sources & evidence

ORD record
ord-4214ce1942974f899913616ceba1db90
Source dataset
uspto-grants-1979_10
Patent number
US04172831

Reaction notes

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