Pyridine → Trifluoromethylpyridine

Temperature

180 °C

In the same reaction vessel as used in Example 1, 15.82 g of pyridine and 7.83 g of trifluoromethyl iodide were mixed. The vessel was airtightly sealed and heated at 180° C. for 24 hours. After the reaction, the reactor was cooled to room temperature. Thereafter, the reaction mixture was removed from the cooled vessel and treated by following the procedure of Example 1. Consequently, there was obtained 1.17 g (19.90% of theoretical value) of trifluoromethyl pyridine. This substance was found to be a 48:41:11 mixture of α, β and γ isomers.

1. additionwere mixed
2. customThe vessel was airtightly sealed
3. customAfter the reaction
4. temperaturethe reactor was cooled to room temperature
5. customThereafter, the reaction mixture was removed from the cooled vessel
6. additiontreated

ORD record

ord-0cfacf94548244c69efdb199f832c1f8

Source dataset

uspto-grants-1979_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04172946